Dave Matthews

Demuris awarded £204,000 grant funding from Innovate UK

Demuris has secured £204,398 grant funding from Innovate UK to develop new molecular methods for global activation of cryptic biosynthetic gene clusters. Actinobacterial Natural Products are an important source of commercially used compounds, including many clinically used antibiotic, antifungal and anticancer compounds. The genes required to produce these compounds are encoded by Biosynthetic Gene Clusters (BGCs). Genomic …

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Demuris publication in ACS Chemical Biology

Mode of Action and Heterologous Expression of the Natural Product Antibiotic Vancoresmycin. Antibiotics that interfere with the bacterial cytoplasmic membrane have long-term potential for the treatment of infectious diseases as this mode of action is anticipated to result in low resistance frequency. Vancoresmycin is an understudied natural product antibiotic consisting of a terminal tetramic acid …

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Professor Jeff Errington awarded the 2017 FEMS-Lwoff Award

The Lwoff Medal is awarded biennially by the Federation of European Microbiological Societies (FEMS) to recognise the achievements of outstanding individuals or groups contributing to the field of microbiology in Europe. Speaking of the Medal Jeff said “I am deeply honoured and humbled by this award. Lwoff is one of my scientific heroes. My early …

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Demuris publication in Journal of Cell Science

Screening and purification of natural products from actinomycetes that affect the cell shape of fission yeast. This study was designed to identify bioactive compounds that alter the cellular shape of the fission yeast Schizosaccharomyces pombe by affecting functions involved in the cell cycle or cell morphogenesis. We used a multidrug-sensitive fission yeast strain, SAK950 to …

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Demuris publication in Journal of Natural Products

Structural Reassignment and Absolute Stereochemistry of Madurastatin C1 (MBJ-0034) and the Related Aziridine Siderophores: Madurastatins A1, B1, and MBJ-0035. The madurastatins are pentapeptide siderophores originally described as containing an unusual salicylate-capped N-terminal aziridine ring. Isolation of madurastatin C1 (1) (also designated MBJ-0034), from Actinomadura sp. DEM31376 (itself isolated from a deep sea sediment), prompted structural …

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Demuris publication in Nature Microbiology

RodA as the missing glycosyltransferase in Bacillus subtilis and antibiotic discovery for the peptidoglycan polymerase pathway. The bacterial cell wall is a highly conserved essential component of most bacterial groups. It is the target for our most frequently used antibiotics and provides important small molecules that trigger powerful innate immune responses. The wall is composed …

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